Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
نویسندگان
چکیده
منابع مشابه
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines
Rac1 GTPase has long been recognized as a critical regulatory protein in different cellular and molecular processes involved in cancer progression, including acute myeloid leukemia. Here we show the antitumoral activity of ZINC69391 and 1A-116, two chemically-related Rac1 pharmacological inhibitors, on a panel of four leukemic cell lines representing different levels of maturation. Importantly,...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.21533